10–15% of the AP exam. Key topics: Signal transduction pathway stages: reception, transduction, response, Ligand-receptor specificity and signal amplification via second messengers, Types of cell signaling: endocrine (long-distance), paracrine, autocrine, direct contact (juxtacrine), Cell cycle stages: interphase (G1, S, G2) and mitotic phase (mitosis + cytokinesis), Mitosis stages: prophase, metaphase, anaphase, telophase (PMAT), Cell cycle checkpoints: G1, G2, and spindle assembly checkpoints, Proto-oncogenes, tumor suppressor genes, and cancer as uncontrolled cell division, Apoptosis and its role in development and disease prevention.
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